Owner we tuned a few years ago that has the twin turbo mounted back by mufflers recently desided to change CAM.
After the change engine was not running well and we just retuned it.

Cause was the mods installed

Cam. .228in. /.234ex .589 in.lift/ .598 ex on a 120deg. LSA.

New dual springs and new lifters.
New airbridge, NO cats.

9.5 to 1 compression pistons.
Same Lingenfelter LS-6 heads.
60 lb/hr Injectors
Shorty headers.

Before changing CAM the injectors are really too large at 60 lbs/hr.
With the older CAM and higher engine compression the injector duty cycle with use of water/meth injection was 83%

Now without even running the water/meth max duty cycle was only 69%.
Notice the 120 LSA of new CAM.

In this makeup best case is to swap to a 48 lb injector as of now PCM has to command injector pulse width ON less then 2.4 mSec when best would be about 3 mSec and after this tune to lean up how rich engine is now running the pulse width will be even shorter and PCM cannot command well with such ON times